1-脱氧野霉素盐酸盐
基本信息
产品名称 | 1-脱氧野霉素盐酸盐 |
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英文名称 | 1-Deoxynojirimycin Hydrochloride |
英文别名 | Moranoline Hydrochloride; 1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride |
规格或纯度 | ≥95% |
运输条件 | 超低温冰袋运输 |
一般描述
1-盐酸脱氧野霉素是一种葡萄糖类似物,是抑制α-葡萄糖苷酶I和II活性的“糖诱饵”。1-脱氧野霉素被描述为抑制HIV-1在培养的HIV感染的淋巴细胞中传播。1-脱氧野霉素素被证明可增强大鼠中脂联素mRNA的表达,增加血浆脂联素水平并增强AMPK mRNA的表达,从而支持了1-脱氧野霉素抑制人餐后血糖升高的报道。1-盐酸脱氧野霉素是LYAG和β-葡萄糖苷酶的抑制剂。
1-Deoxynojirimycin Hydrochloride is a glucose analog and “saccharide decoy” that inhibits α-glucosidase I and II activity. 1-Deoxynojirimycin is described to inhibit HIV-1 spread in cultured HIV-infected lymphocytes. 1-Deoxynojirimycin is demonstrated to enhance the expression of adiponectin mRNA, increase plasma adiponectin levels, and enhance expression of AMPK mRNA in rats, supporting reports that 1-Deoxynojirimycin suppresses postprandial blood glucose increases in humans. 1-Deoxynojirimycin Hydrochloride is an inhibitor of LYAG and β-glucosidase.
相关属性
CAS编号 | 73285-50-4 |
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熔点 | 208-210° C |
pKa值 | pKa: 13.77 (Predicted), pKa: 7.53 (Predicted) |
溶解性 | Soluble in water (Partly miscible), methanol, DMSO (~10 mg/ml), and PBS,pH 7.2 (~1 mg/ml). |
储存温度 | -20°C储存 |
分子量 | 199.63 |
分子式 | C6H14ClNO4 |
品牌 | Jinpan |
Smiles | C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O.Cl |
IC50 | alpha-glucosidase: IC₅₀= 1.8 μM (saccharomyces cerevisiae); alpha-glucosidase: IC₅₀= 2.4 μM (bacillus stearothermophilus ) |
PubChem CID | 13018787 |