Alamethicin F50

Alamethicin F50是具有强抗生素活性的中性线性肽复合物，包含由木霉属（Trichoderma sp）生产的20个带有乙酰基和苯丙氨醇末端的“氨基酸”。Alamethicin F50发挥离子渗透作用，通过膜和人造脂质膜转运离子。Alamethicin F50在脂质双层膜中形成电压依赖性离子通道。Alamethicin F50与酸性线性肽前体复合物（alamethicin F30）共同生产。阿拉美霉素本身是酸性和中性成分的可变混合物。通常，关于杀虫菊酯的报道并未指定复合物中F50与F30的比例，并

Alamethicin F50 is a neutral linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids” with an acetyl and phenylalaninol termini, produced by|Trichoderma sp|. Alamethicin F50 acts an ionopohore, transporting ions through membranes and artificial lipid membranes. Alamethicin F50 forms voltage- dependent ion channels in lipid bilayer membranes. Alamethicin F50 is co-produced with an acidic linear peptaibol complex (alamethicin F30). Alamethicin itself is a variable mixture of the acidic and neutral components. In general, reports on alamethicin do not specify the ratio of F50 to F30 in the complex and comparative data between the complexes is scant.