A54556A
对革兰氏阳性和革兰氏阴性细菌有活性的有效抗生素
有货
基本信息
| 产品名称 | A54556A |
|---|---|
| 英文名称 | A54556A |
| 运输条件 | 超低温冰袋运输 |
一般描述
A54556A是分离自链霉菌的不寻常的二肽，具有三烯酮侧链。它对革兰氏阳性和革兰氏阴性细菌（包括MRSA）有效。A54556A是最近重新发现的酰基肽肽（ADEP）抗生素的原始先导结构，其通过激活和失活Clp家族蛋白发挥作用。ADEP被认为是开发新一代抗药性抗生素的重要线索。
A54556A is an unusual depsipeptide isolated from|Streptomyces|sp., featuring a trienone side chain. It is potently active against Gram positive and Gram negative bacteria, including MRSA. A54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.
相关属性
| CAS编号 | 95398-45-1 |
|---|---|
| 折光率 | n20D1.61 (Predicted) |
| 沸点 | ~1086.9° C at 760 mmHg (Predicted) |
| 溶解性 | Soluble in ethanol, methanol, DMF, DMSO, and aqueous solutions (sparingly). |
| 储存温度 | -20°C储存 |
| 密度 | ~1.3 g/cm3(Predicted) |
| 分子量 | 718.84 |
| 分子式 | C38H50N6O8 |
| 品牌 | Jinpan |
| Smiles | [C@H]1(C[C@@H]3N(C1)C(=O)[C@H](C)NC([C@H](C)N(C)C([C@@H]2CCCN2C([C@H](COC3=O)NC([C@H](CC4=CC=CC=C4)NC(=O)C=CC=CC=CC)=O)=O)=O)=O)C |
| PubChem CID | 24767779 |