盐酸氟丁酮
基本信息
| 产品名称 | 盐酸氟丁酮 |
|---|---|
| 英文名称 | Halofuginone Hydrochloride |
| 英文别名 | Halofuginone Hydrochloride is also known as HAL. |
| 规格或纯度 | ≥95% |
| 运输条件 | 超低温冰袋运输 |
一般描述
盐氟丁酮是盐氟丁酮的盐酸盐制剂，卤丁酮是抗疟疾生物碱非博古碱的卤代类似物。盐酸哈洛法酮的溴化物和氯化物取代物替代了新陈代谢的易西非替宁的芳香族质子。卤代氟喹酮盐酸盐被描述为产生抗原生动物，抗血管生成和抗增殖作用。也有报道称卤氟丁酮盐酸盐抑制1型胶原蛋白的生物合成。盐酸卤丁酮可在多种不同模型中阻断纤维化和肿瘤进展。
Halofuginone Hydrochloride is the hydrochloride salt preparation of Halofuginone, a halogenated analog of the antimalarial alkaloid febrifugine. The bromide and chloride substitutions of Halofuginone Hydrochloride replace the metabolically vulnerable aromatic protons of febrifugine. Halofuginone Hydrochloride is described to produce antiprotozoal, antiangiogenic, and antiproliferative effects. Halofuginone Hydrochloride is also reported to inhibit the biosynthesis of type 1 collagen. Halofuginone Hydrochloride blocks fibrosis and tumor progression in a variety of different models.
相关属性
| CAS编号 | 1217623-74-9 |
|---|---|
| 折光率 | n20D1.71 (Predicted) |
| 熔点 | 237-242° C (dec.) |
| pKa值 | pKa: 8.73 |
| 溶解性 | Soluble in DMSO, and methanol. |
| 储存温度 | -20°C储存 |
| RTECS | VA2397066 |
| 分子量 | 451.14 |
| 分子式 | C16H18BrCl2N3O3 |
| 品牌 | Jinpan |
| 备注 | Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Packaged under inert gas, protect from light. |
| Smiles | Cl.OC1CCCN[C@H]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=O |
| PubChem CID | 71317187 |