Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,

发表于由

酮康唑

强大的细胞色素P450抑制剂。抗真菌剂。
≥98%

有货

Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,

CAS编号 65277-42-1 | 品牌：Jinpan
Ketoconazole

MSDS

质检证书(CoA)

相似产品

  • 分子式 C26H28Cl2N4O4
  • 分子量531.43
  • EC号 265-667-4
  • MDL号 MFCD00058579
  • PubChem编号 456201

货号 (SKU) 包装规格 是否现货 价格 数量
K129737-1g 1g 现货 Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,  
K129737-5g 5g 现货 Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,  
K129737-25g 25g 现货 Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,  
K129737-100g 100g 现货 Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,  
K129737-500g 500g 现货 Cas(65277-42-1), 酮康唑, Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone,Ketoconazole,  

基本信息

产品名称 酮康唑
英文名称 Ketoconazole
别名 (±)-顺-1-乙酰基-4-(4-[(2-[2,4-二氯苯基]-2-[1H-咪唑-1-基甲基]-1,3-二氧戊环-4-基)-甲氧基]苯基)哌嗪; 顺-1-乙酰基-4-[4-[[2-(2,4-二氯苯基)-2-(1H-咪唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪
英文别名 Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone;(±)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy
规格或纯度 ≥98%
运输条件 冰袋运输
生化机理 有力的细胞色素P450抑制剂（CYP3A4和CYP3A5的K i值分别为26.7和109 nM）。抗真菌剂。另外，显示对人雄激素受体的活性。

一般描述

Ketoconazole is an imidazole-containing small molecule inhibitor of cytochrome P-450-dependent steps in the biosynthesis of steroid hormones; also inhibits TXA Synthase (thromboxane synthetase) and 5-LO (5-lipoxygenase) activity. Ketoconazole exhibits antimetastatic, antineoplastic, and antipsoriatic activity. Inhibition of 5-LO (5-lipoxygenase) by Ketoconazole interrupts arachidonic acid -derived leukotriene production, which was correlated to a suppression of leukotriene-mediated anaphylactic bronchoconstriction in guinea pigs. Ketoconazole is described as reducing platelet cellular levels of thromboxane A2, suppressing thromboxane A2-mediated increase of microvascular permeability in response to ischemia insults. Ketoconazole produces an antiandrogen effect through inhibition of adrenocorticoid biosynthesis, suppressing the adrenal secretion of androgens and attenuating cortisol response. Ketoconazole is an inhibitor of CYP17A1, CYP3A4 and CYP3A5
An inhibitor of CYP proteins, thromboxane synthetase, and 5-LO

相关属性

CAS编号 65277-42-1
敏感性 对热敏感
熔点 150 °C
溶解性 Soluble in DMSO (20 mg/mL warm), ethanol (20 mg/mL warm), chloroform, water (<1 mg>
储存温度 2-8°C储存
Reaxys-RN 5488107
RTECS TK7912300
MDL号 MFCD00058579
分子量 531.43
分子式 C26H28Cl2N4O4
EC号 265-667-4
品牌 Jinpan
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PubChem CID 456201