更昔洛韦 水合物
抗病毒化合物。抑制DNA复制。
≥98.0%
有货
基本信息
| 产品名称 | 更昔洛韦 水合物 |
|---|---|
| 英文名称 | Ganciclovir |
| 别名 | 9-[[2-羟基-1-(羟甲基)乙氧基]甲基]鸟嘌呤；更息洛韦；丙氧鸟苷 |
| 英文别名 | BW 759; 2′-Nor-2′-deoxyguanosine;2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2′-NDG; |
| 应用 | A nucleoside analog structurally related to Acyclovir. |
| 规格或纯度 | ≥98.0% |
| 运输条件 | 冰袋运输 |
| 生化机理 | Ganciclovir is a nucleoside analog structurally related to Acyclovir that acts as a prodrμg activated by phosphorylation. Ganciclovir has been used in the study of “suicide” gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrμg ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.Anti-viral compound. Inhibits viral replication by competitively inhibiting incorporation of dGTP into viral DNA. Active in vivo . |
一般描述
Ganciclovir 是一种抗病毒药，作用于猫科动物1型疱疹病毒，IC50为5.2 μM。A nucleoside analog structurally related to Acyclovir.
Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.
A nucleoside analog structurally related to Acyclovir.
相关属性
| CAS编号 | 82410-32-0 |
|---|---|
| 敏感性 | 对热敏感 |
| 熔点 | 250°C(dec.)(lit.) |
| 溶解性 | Soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg> |
| 储存温度 | 2-8°C储存 |
| Reaxys-RN | 3654487 |
| RTECS | MF8407000 |
| MDL号 | MFCD00870588 |
| 分子量 | 255.23 |
| 分子式 | C9H13N5O4 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 135398740 |