硝呋齐特
JAK / STAT信号抑制剂。硝基呋喃抗生素。
≥98%
有货
基本信息
| 产品名称 | 硝呋齐特 |
|---|---|
| 英文名称 | Nifuroxazide |
| 别名 | 硝呋齐特 |
| 英文别名 | 5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone;p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide |
| 规格或纯度 | ≥98% |
| 运输条件 | 冰袋运输 |
| 生化机理 | Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation.JAK/STAT signaling inhibitor. Nitrofuran antibiotic. Inhibits JAK2 and Tyk2 phosphorylation and subsequent downstream STAT3 inhibition (EC 50 = 3 μM). Antidiarrheal. Shows little effect on Akt, NF-κB, JAK1, MAPK and Src signaling. |
一般描述
An inhibitor of STAT activation and signaling activity
An inhibitor of STAT activation and signaling activity
相关属性
| CAS编号 | 965-52-6 |
|---|---|
| 敏感性 | 对光敏感、对空气敏感、对热敏感 |
| 熔点 | 281-283°C |
| 溶解性 | Soluble in water (practically insoluble), chloroform (practically insoluble), ethyl ether (0.01g/>100ml) (practically insoluble), Methanol (0.01g/100ml) (very slightly soluble), 1 N Sodium hydroxide (1.0g/30ml), and DMSO. |
| 储存温度 | 2-8°C储存 |
| MDL号 | MFCD00079482 |
| 分子量 | 275.22 |
| 分子式 | C12H9N3O5 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 5337997 |