Corynecin III

Corynecin III（甲氨蝶呤）是1972年从碳棒杆菌中分离出的氯霉素样酰基硝基苯基丙胺的天然复合物的成员。CorynecinIII对革兰氏阳性和革兰氏阴性细菌有活性。尽管棒状杆菌素Ⅲ的效力不如氯霉素，但显示出相似的物种选择性。棒棒糖III用作氯霉素的生物同工异构体，以检查氯霉素与DraE毒力因子的结合关系。

Corynecin III (methamphenicol) is a member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from|Corynebacterium hydrocarboclastus|in 1972. Corynecin III is active against Gram positive and Gram negative bacteria. Although less potent than chloramphenicol, corynecin III shows a similar species selectivity. Corynecin III was used as a bioisostere of chloroamphenicol to examine the binding relationship of chloramphenicols to DraE virulence factor.