Celastramycin A
从内生细菌中分离出来的生物活性化合物
有货
基本信息
| 产品名称 | Celastramycin A |
|---|---|
| 英文名称 | Celastramycin A |
| 英文别名 | (3-chloro-5-hexyl-2,6-dihydroxyphenyl)(4,5-dichloro-1H-pyrrol-3-yl)-methanone |
| 运输条件 | 超低温冰袋运输 |
一般描述
Celastramycin A是从生活在Celastraceae家族植物中的内生细菌分离的生物活性化合物。该苯甲酰基吡咯抑制细菌和分枝杆菌的生长，最小抑制浓度低至0.05μg/ ml。Celastramycin A还可以抑制肿瘤坏死因子-α（IC50 = 0.01μg/ ml）刺激的人脐静脉内皮细胞中白细胞介素8的产生。
Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family. This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml. Celastramycin A also suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α (IC50 = 0.01 μg/ml).
相关属性
| CAS编号 | 491600-94-3 |
|---|---|
| 折光率 | n20D~1.62 (Predicted) |
| 熔点 | 218.29° C (Predicted) |
| 沸点 | 516.47° C at 760 mmHg (Predicted) |
| 溶解性 | Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:4 ethanol:PBS(pH 7.2) (~0.2 mg/ml). |
| 储存温度 | -20°C储存 |
| 密度 | ~1.41 g/cm3(Predicted) |
| 分子量 | 390.7 |
| 分子式 | C₁₇H₁₈Cl₃NO₃ |
| 品牌 | Jinpan |
| Smiles | ClC1=CC(CCCCCC)=C(O)C(C(C2=CC(Cl)=C(Cl)N2)=O)=C1O |
| IC50 | Suppress the production of interleukin-8: IC₅₀= 0.01 μg/ml (human) |