上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Compound E (Synonyms: γ-Secretase-IN-1) 纯度: 99.91%
Compound E 是 γ-secretase 抑制剂。 Compound E 抑制 β-amyloid(40),β-amyloid(42),和Notch γ-分泌酶切割的 IC50 值分别为 0.24,0.37,0.32 nM。
Compound E Chemical Structure
CAS No. : 209986-17-4
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥1600 | In-stock | |
5 mg | ¥5200 | In-stock | |
10 mg | ¥9200 | In-stock | |
25 mg | ¥19000 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Compound E 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. |
IC50 & Target |
IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)[1] |
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体外研究 (In Vitro) |
Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
490.50 |
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Formula |
C27H24F2N4O3 |
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CAS 号 |
209986-17-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:
DMSO : 115 mg/mL (234.45 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [1] |
The breast cancer cell lines MDA-MB-231, T47D, and MCF-7 are treated with Compound E at concentrations in the range 0.01-50 μM for 48 h and their viability is determined using a Coulter counter[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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