Calyculin A(Synonyms: (-)-Calyculin A)

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Calyculin A (Synonyms: (-)-Calyculin A) 纯度: ≥99.0%

Calyculin A ((-)-Calyculin A) 是有效，可渗透细胞的蛋白磷酸酶 1 (PP1) 和蛋白磷酸酶 2A (PP2A) 抑制剂，其 IC50 值分别为 2 nM 和 0.5-1 nM。

Calyculin A(Synonyms: (-)-Calyculin A)

Calyculin A Chemical Structure

CAS No. : 101932-71-2

规格 价格 是否有货 数量
10 μg (0.5 mM * 20 μL in DMSO) ￥1200 In-stock
25 μg (0.5 mM * 50 μL in DMSO) ￥2050 In-stock
50 μg (0.5 mM * 100 μL in DMSO) ￥3680 In-stock
100 μg (0.5 mM * 200 μL in DMSO) ￥5530 In-stock

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生物活性

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively[1].

IC50 & Target

IC50: 2 nM (PP1); 0.5-1 nM (PP2A)[1]
体外研究
(In Vitro)

Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner up to 10 nM in MG63 cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Human osteosarcoma MG63 cells
Concentration: 0, 1, 2, 5, 10 nM
Incubation Time: 24 hours
Result: Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.

分子量

1009.17

Formula

C50H81N4O15P
CAS 号

101932-71-2
中文名称

花萼海绵诱癌素；花萼海绵体诱癌素A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
参考文献

  • [1]. Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7.

    [2]. Hiroaki Tanaka,et al. Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. Int J Oncol. 2007 Aug;31(2):389-96.

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