放线菌素D
来自链霉菌。,≥95%（HPLC）
有货
基本信息
| 产品名称 | 放线菌素D |
|---|---|
| 英文名称 | Actinomycin D |
| 英文别名 | Dactinomycin, Actinomycin IV, Actinomycin C₁ |
| 规格或纯度 | 来自链霉菌。,≥95%（HPLC） |
| 运输条件 | 冰袋运输 |
| 生化机理 | 放线菌素 D 通过与双链 DNA 形成稳定的复合物，抑制 DNA 引发的 RNA 合成并引起 DNA 的单链断裂来抑制细胞的增殖。 研究表明，它是逆转录酶中负链转移步骤的抑制剂。 |
一般描述
Description
Chemical structure: peptideActinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas. Recommended for us in cell culture applications at 1μg/mL.
Preparation instructions
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
相关属性
| CAS编号 | 50-76-0 |
|---|---|
| 熔点 | 251-253°C |
| 溶解性 | 乙醇, ; DMSO：可溶 |
| 储存温度 | 2-8°C储存 |
| MDL号 | MFCD00005033 |
| 分子量 | 1255.438 |
| 分子式 | C62H86N12O16 |
| 品牌 | Jinpan |
| PubChem CID | 126963444 |