放线菌素D
来自链霉菌sp.,~98%（HPLC）
有货
基本信息
| 产品名称 | 放线菌素D |
|---|---|
| 英文名称 | Actinomycin D |
| 英文别名 | Dactinomycin, Actinomycin IV, Actinomycin C₁ |
| 规格或纯度 | 来自链霉菌sp.,~98%（HPLC） |
| 运输条件 | 冰袋运输 |
| 生化机理 | 放线菌素 D 通过与双链 DNA 形成稳定的复合物，抑制 DNA 引发的 RNA 合成并引起 DNA 的单链断裂来抑制细胞的增殖。 研究表明，它是逆转录酶中负链转移步骤的抑制剂。 |
一般描述
Description
Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.Chemical structure: peptideActinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas.
Preparation instructions
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
相关属性
| CAS编号 | 50-76-0 |
|---|---|
| 熔点 | 251-253°C |
| 溶解性 | DMSO：1mg/mL；乙醇：可溶 |
| 储存温度 | 2-8°C储存 |
| MDL号 | MFCD00005033 |
| 分子量 | 1255.438 |
| 分子式 | C62H86N12O16 |
| 品牌 | Jinpan |
| PubChem CID | 126963444 |