NSC5844(Synonyms: RE-640)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NSC5844 (Synonyms: RE-640) 纯度: ≥98.0%

NSC5844 (RE-640) 是 4-氨基喹啉衍生物，具有抗肿瘤和抗疟疾 (antimalarial) 活性。

NSC5844(Synonyms: RE-640)

NSC5844 Chemical Structure

CAS No. : 140926-75-6

规格 价格 是否有货 数量
1 mg ￥770 In-stock
5 mg ￥2300 In-stock
10 mg ￥3000 In-stock
25 mg ￥4500 In-stock
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NSC5844 相关产品

•相关化合物库:

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生物活性

NSC5844 (RE-640) is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.

IC50 & Target

Parasite[2]
体外研究
(In Vitro)

NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

383.27

Formula

C20H16Cl2N4
CAS 号

140926-75-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Zhang H, et al. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed Pharmacother. 2008 Feb;62(2):65-9. Epub 2007 May 24.

    [2]. Vennerstrom JL, et al. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29;35(11):2129-34.

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