上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
BC-DXI-843 纯度: 98.73%
BC-DXI-843 是一种有效的特异性 AIMP2-DX2 抑制剂,IC50 为 0.92 μM,比作用于 AIMP2 (IC50 >100 μM) 选择性高 100 倍以上。BC-DXI-843 有潜力用于 AIMP2-DX2 肺癌的研究。
BC-DXI-843 Chemical Structure
CAS No. : 2421117-98-6
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
5 mg | ¥1150 | In-stock | |
10 mg | ¥1900 | In-stock | |
25 mg | ¥3500 | In-stock | |
50 mg | ¥5300 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
BC-DXI-843 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
- Anti-Lung Cancer Compound Library
- Targeted Diversity Library
生物活性 |
BC-DXI-843 is a potent and specific AIMP2-DX2 inhibitor with an IC50 of 0.92 μM, more than 100-fold selectivity over AIMP2 (IC50 >100 μM) in a luciferase assay. BC-DXI-843 acts as a promising lead targeting AIMP2-DX2 in lung cancer[1]. |
IC50 & Target |
IC50: 0.92 μM (AIMP2-DX2), IC50: >100 μM (AIMP2)[1] |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
BC-DXI-843 (0.0316-31.6 μM; 72 hours) suppresses cancer cell proliferation in a DX2-dependent manner. The EC50 in A549 cells is 1.20 μM, which is similar to the IC50 for inhibition of DX2. However, no inhibition of WI-26 cells is observed, suggesting that BC-DXI-843 specifically reduces the viability of cancer cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
|
||||||||||||||||
体内研究 (In Vivo) |
BC-DXI-843 (50 mg/kg; intraperitoneally administered; every other day for 15 days) demonstrates in vivo efficacy in a tumor xenograft mouse model (H460 cells)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||
分子量 |
546.66 |
||||||||||||||||
Formula |
C28H26N4O4S2 |
||||||||||||||||
CAS 号 |
2421117-98-6 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (457.32 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务