上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
AGN 205728
AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。
AGN 205728 Chemical Structure
CAS No. : 859498-05-8
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| 生物活性 |
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. IC50 value: 3 nM/ 0.6 nM(Ki/IC95) Target: RARγ antagonist More information can be found in the following patent, Compound 7a. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A. From PCT Int. Appl. (2005), WO 2005066115 A2 20050721. |
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| 分子量 |
437.53 |
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| Formula |
C29H27NO3 |
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| CAS 号 |
859498-05-8 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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