Bragsin2

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Bragsin2  纯度: 99.85%

Bragsin2 是一种有效、选择性、和非竞争性的核苷酸交换因子 BRAG2 抑制剂，IC50 值为 3 μM。Bragsin2 结合于 BRAG2 的 PH 结构域和磷脂双分子层的界面处，导致 BRAG2 无法激活磷脂化的 Arf GTPase。Bragsin2 能够影响乳腺癌干细胞。

Bragsin2

Bragsin2 Chemical Structure

CAS No. : 342795-08-8

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5 mg ￥7500 In-stock
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生物活性

Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].

IC50 & Target

IC50: 3 μM (BRAG2)[1]
体外研究
(In Vitro)

Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1].
Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

289.16

Formula

C11H6F3NO5
CAS 号

342795-08-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.

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