Rosabulin(Synonyms: STA 5312)

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Rosabulin (Synonyms: STA 5312) 纯度: 98.72%

Rosabulin (STA 5312) 是一种有效的具有口服活性的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

Rosabulin(Synonyms: STA 5312)

Rosabulin Chemical Structure

CAS No. : 501948-05-6

规格 价格 是否有货 数量
5 mg ￥3800 In-stock
10 mg ￥6000 In-stock
25 mg ￥11500 In-stock
50 mg   询价  
100 mg   询价  

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Rosabulin 相关产品

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生物活性

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity[1].

体外研究
(In Vitro)

Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

400.45

Formula

C22H16N4O2S
CAS 号

501948-05-6
中文名称

罗沙布林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (124.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4972 mL 12.4860 mL 24.9719 mL
5 mM 0.4994 mL 2.4972 mL 4.9944 mL
10 mM 0.2497 mL 1.2486 mL 2.4972 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Keizo Koya,et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Cancer Res, Volume 45, 2004.

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