(Rac)-Lys-SMCC-DM1(Synonyms: (Rac)-Lys-Nε-MCC-DM1)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(Rac)-Lys-SMCC-DM1 (Synonyms: (Rac)-Lys-Nε-MCC-DM1) 纯度: 98.18%

(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) 是 Lys-SMCC-DM1 (HY-101982) 的消旋体。是一种有效地连接子-载荷 (payload) 组分，具有抑制微管蛋白聚合的潜力。Lys-SMCC-DM1 是 T-DM1 的活性代谢产物。

(Rac)-Lys-SMCC-DM1(Synonyms: (Rac)-Lys-Nε-MCC-DM1)

(Rac)-Lys-SMCC-DM1 Chemical Structure

规格 价格 是否有货 数量
1 mg ￥3500 In-stock
5 mg ￥9500 In-stock
10 mg ￥14500 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1 (HY-101982). Lys-SMCC-DM1 is a linker-payload component that has the potential to inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1[1].

IC50 & Target[1]

Maytansinoids

 

分子量

1103.71

Formula

C53H75ClN6O15S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.

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