上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
GW779439X 纯度: 99.85%
GW779439X,吡唑并吡啶类化合物,是一种金黄色葡萄球菌 PASTA 激酶 Stk1 抑制剂。GW779439X 增强 β-内酰胺类抗生素对各种 MRSA 和 MSSA 的分离株,有的甚至跨越了从耐药到敏感的断点。GW779439X 是一种 AURKA 抑制剂,可通过 caspases 3/7 诱导细胞凋亡 (apoptosis)。
GW779439X Chemical Structure
CAS No. : 551919-98-3
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1650 | In-stock | |
5 mg | ¥1500 | In-stock | |
10 mg | ¥2500 | In-stock | |
25 mg | ¥5500 | In-stock | |
50 mg | ¥9000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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GW779439X 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- Apoptosis Compound Library
- Cell Cycle/DNA Damage Compound Library
- Epigenetics Compound Library
- Kinase Inhibitor Library
- Anti-Cancer Compound Library
- Autophagy Compound Library
- Anti-Aging Compound Library
- Antibacterial Compound Library
- Cytoskeleton Compound Library
- Anti-Blood Cancer Compound Library
生物活性 |
GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus |
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IC50 & Target[1][2] |
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体外研究 (In Vitro) |
GW779439X (2 μM) biochemically inhibits Stk1. GW779439X (5 μM) potentiates ceftaroline activity against a ceftaroline-resistant MRSA strain. GW779439X is able to potentiate the activity of oxacillin against various S. aureus isolates, including both MRSA and MSSA isolates, but the potentiation is clearly strongest in PBP2A-containing strains[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
454.45 |
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Formula |
C22H21F3N8 |
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CAS 号 |
551919-98-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 31.25 mg/mL (68.76 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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