UK122

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

UK122 

UK122 是一种有效的，选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，IC50 为 0.2 μM。UK122 对组织型 PA (tPA)、纤溶酶、凝血酶和胰蛋白酶没有或几乎没有抑制作用(IC50>100 μM)。UK122 是 4-恶唑烷酮类似物，一种抗癌剂，可抑制癌细胞迁移和侵袭。

UK122

UK122 Chemical Structure

CAS No. : 940290-58-4

规格 价格 是否有货
5 mg ￥2200 询问价格 & 货期
10 mg ￥3500 询问价格 & 货期
25 mg ￥6900 询问价格 & 货期
50 mg ￥11000 询问价格 & 货期

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生物活性

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].

体外研究
(In Vitro)

UK122 (11.1, 33.3, 100 μM; 24 h) dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1].
UK122 (10-100 μM; 48 h) has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

291.30

Formula

C17H13N3O2
CAS 号

940290-58-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.

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