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SNT-207858 free base 纯度: 98.06%
SNT-207858 free base 是一种选择性,能透过血脑屏障的,有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂,SNT-207858 free base 抑制与 MC-4 受体结合,IC50 为 22 nM。SNT-207858 抑制 MC-4 活性,IC50 为 11 nM。
SNT-207858 free base Chemical Structure
CAS No. : 1104662-66-9
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥6100 | In-stock | |
5 mg | ¥4500 | In-stock | |
10 mg | ¥7500 | In-stock | |
50 mg | ¥22500 | In-stock | |
100 mg | ¥33500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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SNT-207858 free base 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Neuronal Signaling Compound Library
- Anti-Cancer Compound Library
- CNS-Penetrant Compound Library
- Endocrinology Compound Library
- Orally Active Compound Library
生物活性 |
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1]. |
IC50 & Target |
MC-4 receptor[1] |
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体外研究 (In Vitro) |
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
616.62 |
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Formula |
C32H43Cl2N5O3 |
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CAS 号 |
1104662-66-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (202.72 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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