Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA | 赛默飞Alfa aesar官网

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Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA 纯度: 99.40%

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 是整合蛋白 αvβ3 的抑制剂，具有抗肿瘤活性。

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA Chemical Structure

CAS No. : 199807-33-5

规格	价格	是否有货
1 mg	￥1700	In-stock
5 mg	￥5200	In-stock
10 mg		询价
50 mg		询价

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生物活性

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.

IC₅₀ & Target

αvβ3^[1]

体外研究
(In Vitro)

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

688.65

Formula

C₂₈H₃₉F₃N₈O₉

CAS 号

199807-33-5

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284.

Cell Assay ^[1]	The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×10⁵ cells/mL in the 2D culture system and 1×10⁶ cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284.

Cell Assay
^[1]

The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×10⁵ cells/mL in the 2D culture system and 1×10⁶ cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284.

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