Triciferol

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Triciferol  纯度: 98.61%

Triciferol 是一种具有 VDR 激动剂和 HDAC 拮抗剂联合作用的多配体。Triciferol 直接与 VDR结合 (IC50=87 nM),在一些 1,25D 靶基因上作为具有 1,25D 样效力的激动剂发挥作用。Triciferol 诱导显著的微管蛋白高乙酰化,并增强组蛋白乙酰化。抗增殖和细胞毒性活性。

Triciferol

Triciferol Chemical Structure

CAS No. : 957214-00-5

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Triciferol 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].

体外研究
(In Vitro)

Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells[1].
Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB231 breast cancer cells
Concentration: 0-10000 nM
Incubation Time: 0-72 hours
Result: Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above.

分子量

429.59

Formula

C26H39NO4

CAS 号

957214-00-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Tavera-Mendoza LE, et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc Natl Acad Sci U S A. 2008;105(24):8250-8255.

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