上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
HS-27 纯度: 98.48%
HS-27,一种荧光 Hsp90 抑制剂,检测完整组织标本表面 Hsp90 的表达。HS-27 由 SNX-5422 的核心元素组成,SNX-5422 是一种 Hsp90 抑制剂,通过 PEG 连接物与荧光素衍生物 (异硫氰酸荧光素或 FITC) 连接,后者与外周表达的 Hsp90 结合。HS-27 在乳腺癌的观察与研究中有潜在的应用。
HS-27 Chemical Structure
CAS No. : 1562024-11-6
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥6340 | In-stock | |
5 mg | ¥3500 | In-stock | |
10 mg | ¥5800 | In-stock | |
25 mg | ¥11000 | In-stock | |
50 mg | ¥17000 | In-stock | |
100 mg | ¥25000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
HS-27 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Endoplasmic Reticulum Stress Compound Library
- Pyroptosis Compound Library
- Cytoskeleton Compound Library
- Anti-Breast Cancer Compound Library
生物活性 |
HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. HS-27 fluorescence is greater in tumor than non-tumor tissue[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
993.13 |
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Formula |
C52H60N6O12S |
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CAS 号 |
1562024-11-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (125.86 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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