上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Lactimidomycin 纯度: ≥98.0%
Lactimidomycin 是从链霉菌中分离出的含戊二酰亚胺的化合物。Lactimidomycin 是一种有效的真核翻译延伸抑制剂,对肿瘤细胞系具有有效的抗增殖作用,并选择性抑制蛋白质翻译。Lactimidomycin 抑制蛋白质合成,IC50 值为 37.82 nM。Lactimidomycin 还是登革热病毒 2 和其他 RNA 病毒的有效且无毒的抑制剂。抗癌和抗病毒活性。
Lactimidomycin Chemical Structure
CAS No. : 134869-15-1
规格 | 价格 | 是否有货 | 数量 |
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200 μg | ¥9700 | In-stock |
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生物活性 |
Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC50 value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities[1][2]. |
IC50 & Target |
Eukaryotic translation elongation[1] |
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体外研究 (In Vitro) |
Lactimidomycin (0.01-100 nM; 24 hours; Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A) treatment inhibits cell growth with IC50 concentrations in the low nanomolar range, but higher doses are necessary to inhibit growth of the non-tumorigenic breast cell line MCF10A[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
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体内研究 (In Vivo) |
Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
457.56 |
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Formula |
C26H35NO6 |
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CAS 号 |
134869-15-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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