Monophosphoryl lipid A(Synonyms: Glucopyranosyl lipid A)

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Monophosphoryl lipid A (Synonyms: Glucopyranosyl lipid A)

Monophosphoryl lipid A (Glucopyranosyl lipid A) 是一种 toll-like receptor 4 激动剂。Monophosphoryl lipid A 来源于非致病性沙门氏菌的细胞壁。Monophosphoryl lipid A 可用于免疫和疫苗研究。

Monophosphoryl lipid A(Synonyms: Glucopyranosyl lipid A)

Monophosphoryl lipid A Chemical Structure

CAS No. : 1246298-63-4

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生物活性

Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine[1].

IC50 & Target[1]

TLR4

 

体外研究
(In Vitro)

Monophosphoryl lipid A (100 μg/ml, 2 hours; dendritic cells) induces NF-κB activation and modulates TLR2[2].
Monophosphoryl lipid A (5~100 μg/ml, 24 hours; dendritic cells) induces IL-12 production by human[2].
Increasing the amount of Monophosphoryl lipid A (from 0.1 to 1 μg), the percentage of matured BMDCs also increased[1]. Monophosphoryl lipid A up-regulates dendritic cells surface markers. Monophosphoryl lipid A enhances T cell responses. Monophosphoryl lipid A (CD4 T cells) increases calcium mobilization of activated T cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Dendritic cells
Concentration: 100 μg/ml
Incubation Time: 2 hours
Result: Induced NF-κB activation and modulated TLR2.

体内研究
(In Vivo)

The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1763.47

Formula

C96H184N3O22P
CAS 号

1246298-63-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Cheng R, et al. Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines. ACS Appl Mater Interfaces. 2020;12(40):44554-44562.

    [2]. Ismaili J, et al. Monophosphoryl lipid A activates both human dendritic cells and T cells. J Immunol. 2002;168(2):926-932.

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