3-Phenyltoxoflavin

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3-Phenyltoxoflavin  纯度: 99.86%

3-Phenyltoxoflavin 是 Toxoflavin 的衍生物，是一种 Hsp90 抑制剂，抑制 Hsp90-TPR2A 之间相互作用的 Kd 值为 585 nM。3-Phenyltoxoflavin 具有抗癌活性。

3-Phenyltoxoflavin

3-Phenyltoxoflavin Chemical Structure

CAS No. : 32502-63-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3300 In-stock
5 mg ￥3000 In-stock
10 mg ￥5000 In-stock
25 mg ￥9800 In-stock
50 mg ￥15500 In-stock
100 mg ￥23500 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].

IC50 & Target[1]

HSP90

585 nM (Kd)

体外研究
(In Vitro)

3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1].
3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

269.26

Formula

C13H11N5O2
CAS 号

32502-63-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 7.14 mg/mL (26.52 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7139 mL 18.5694 mL 37.1388 mL
5 mM 0.7428 mL 3.7139 mL 7.4278 mL
10 mM 0.3714 mL 1.8569 mL 3.7139 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54.

    [2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.

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