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Zapnometinib (Synonyms: PD0184264; ATR-002) 纯度: 99.63%
Zapnometinib (PD0184264) 是 CI-1040 的活性代谢物,是一种 MEK 抑制剂,IC50 值为 5.7 nM。Zapnometinib 具有抗流感病毒的抗病毒活性和抗菌活性。
Zapnometinib Chemical Structure
CAS No. : 303175-44-2
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥600 | In-stock | |
10 mg | ¥900 | In-stock | |
25 mg | ¥1100 | In-stock | |
50 mg | ¥2050 | In-stock | |
100 mg | ¥3950 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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Zapnometinib 相关产品
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生物活性 |
Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities[1][2][3]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Zapnometinib (0.1 nM-1 μM) inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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体内研究 (In Vivo) |
Zapnometinib (8.4-75 mg/kg/day; three times a day p.o.) reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
409.55 |
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Formula |
C13H7ClF2INO2 |
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CAS 号 |
303175-44-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL (152.61 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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