CWP232228

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CWP232228  纯度: 98.31%

CWP232228 是一种高效的选择性 Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子 (TCF) 结合。CWP232228 通过抑制乳腺癌和肝癌干细胞 (CSCs) 的生长来抑制肿瘤的形成和转移而无毒性。

CWP232228

CWP232228 Chemical Structure

CAS No. : 1144044-02-9

规格 价格 是否有货 数量
5 mg ￥6000 In-stock
10 mg ￥9000 In-stock
50 mg   询价  
100 mg   询价  

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CWP232228 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Stem Cell Signaling Compound Library
  • Wnt/Hedgehog/Notch Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Differentiation Inducing Compound Library
  • Cytoskeleton Compound Library
  • Neuroprotective Compound Library
  • Anti-Breast Cancer Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs)[1].

IC50 & Target

Wnt/β-catenin[1]
体外研究
(In Vitro)

CWP232228 (0.01-100 μM; 48 hours) inhibits cell proliferation with IC50 values are 2 and 0.8 μM in mouse (4T1) and human (MDA-MB-435) breast cancer cell lines, respectively[1].
CWP232228 (0.01-10 μM; 48 hours) inhibits cell proliferation with IC50s of 2.566, 2.630, and 2.596 μM in Hep3B, Huh7 and HepG2 cells, respectively[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Mouse (4T1) and human (MDA-MB-435) breast cancer cell lines
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 hours
Result: IC50s were 2 and 0.8 μM for 4T1 and MDA-MB-435 cell lines, respectively.

Cell Proliferation Assay[2]

Cell Line: Hepatocellular carcinoma cell lines HepG2, Huh7, and Hep3B
Concentration: 0.01, 0.1, 0.5, 1, 5, 10 μM
Incubation Time: 48 hours
Result: IC50s were 2.566, 2.630, and 2.596 μM for Hep3B, Huh7 and HepG2 cells, respectively.

体内研究
(In Vivo)

CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old female Balb/c and NOD/SCID mice bearing 4T1 or MDA-MB-435 cell tumors[1]
Dosage: 100 mg/kg
Administration: Administered i.p.; daily; 21days for mice bearing 4T1 cell tumors, 60 days for mice bearing MDA-MB-435 cell tumors
Result: Treatment resulted in a significant reduction in tumor volume.

分子量

717.62

Formula

C33H34N7Na2O7P
CAS 号

1144044-02-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 62.5 mg/mL (87.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3935 mL 6.9675 mL 13.9350 mL
5 mM 0.2787 mL 1.3935 mL 2.7870 mL
10 mM 0.1393 mL 0.6967 mL 1.3935 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jang GB, et al. Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells. Cancer Res. 2015 Apr 15;75(8):1691-702.

    [2]. Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.

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