SID 3712249(Synonyms: MiR-544 Inhibitor 1)

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SID 3712249 (Synonyms: MiR-544 Inhibitor 1) 纯度: 98.35%

SID3712249 (MIR-544 Inhibitor 1) 是微小 RNA-544 (miR-544) 的生物合成抑制剂。

SID 3712249(Synonyms: MiR-544 Inhibitor 1)

SID 3712249 Chemical Structure

CAS No. : 522606-67-3

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥935 In-stock
5 mg ￥850 In-stock
10 mg ￥1450 In-stock
25 mg ￥3100 In-stock
50 mg ￥4950 In-stock
100 mg ￥7950 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

SID 3712249 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Epigenetics Compound Library
  • Anti-Cancer Compound Library
  • Anti-Breast Cancer Compound Library

生物活性

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544 MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

分子量

323.40

Formula

C17H21N7
CAS 号

522606-67-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 16.67 mg/mL (51.55 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0921 mL 15.4607 mL 30.9215 mL
5 mM 0.6184 mL 3.0921 mL 6.1843 mL
10 mM 0.3092 mL 1.5461 mL 3.0921 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5.

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