GLPG0634 analog

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GLPG0634 analog  纯度: 98.58%

GLPG0634 (analog) 是一种 JAK 广谱性抑制剂，对 JAK1/JAK2/JAK3 的 IC50 值为 50-200 nM。

GLPG0634 analog

GLPG0634 analog Chemical Structure

CAS No. : 1206101-20-3

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1100 In-stock
5 mg ￥1000 In-stock
10 mg ￥2800 In-stock
50 mg ￥6000 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.

IC50 & Target[3]

JAK3

<100 nM (IC50)

Tyk2

<100 nM (IC50)

分子量

410.43

Formula

C23H18N6O2
CAS 号

1206101-20-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : ≥ 53 mg/mL (129.13 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4365 mL 12.1823 mL 24.3647 mL
5 mM 0.4873 mL 2.4365 mL 4.8729 mL
10 mM 0.2436 mL 1.2182 mL 2.4365 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. http://www.google.com/patents/WO2013173506A2cl=en

    [2]. http://www.google.it/patents/WO2010149769A1cl=en

    [3]. http://www.google.com/patents/WO2010010190A1cl=en

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