上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Thalidomide-5,6-F 纯度: 99.84%
Thalidomide-5,6-F 是一种基于 Thalidomide 的,可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5,6-F 可通过 linker 与靶蛋白配体连接,形成 PROTAC 分子。
Thalidomide-5,6-F Chemical Structure
CAS No. : 1496997-41-1
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100 mg | ¥400 | In-stock | |
500 mg | ¥1200 | In-stock | |
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5 g | 询价 |
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Thalidomide-5,6-F 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
- Ubiquitination Compound Library
生物活性 |
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
294.21 |
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Formula |
C13H8F2N2O4 |
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CAS 号 |
1496997-41-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (113.29 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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