F16

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

F16  纯度: 99.92%

F16 是 neu 过表达细胞的有效生长抑制剂，还可以选择性抑制乳腺上皮以及多种小鼠乳腺肿瘤和人乳腺癌细胞系的增殖。F16 是线粒体毒性化合物，根据靶癌细胞的遗传背景触发凋亡或坏死。

F16

F16 Chemical Structure

CAS No. : 36098-33-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥605 In-stock
10 mg ￥550 In-stock
25 mg ￥1100 In-stock
50 mg ￥1900 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

F16 相关产品

•相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Anti-Breast Cancer Compound Library
  • Targeted Diversity Library

生物活性

F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[1][2].

体外研究
(In Vitro)

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines[1].
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
Concentration: 3 μM
Incubation Time: 3 days/7 days
Result: Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.

Clinical Trial

分子量

362.21

Formula

C16H15IN2
CAS 号

36098-33-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : ≥ 31 mg/mL (85.59 mM)

Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7608 mL 13.8041 mL 27.6083 mL
5 mM 0.5522 mL 2.7608 mL 5.5217 mL
10 mM 0.2761 mL 1.3804 mL 2.7608 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42.

    [2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36.

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