ZINC13466751

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ZINC13466751  纯度: 98.62%

ZINC13466751 是一种 HIF-1α/von Hippel-Lindau 相互作用的有效抑制剂,IC50 值为 2.0 µM。

ZINC13466751

ZINC13466751 Chemical Structure

CAS No. : 117953-17-0

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥2750 In-stock
5 mg ¥2500 In-stock
10 mg ¥4000 In-stock
50 mg ¥11500 In-stock
100 mg ¥17000 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 µM[1].

IC50 & Target

IC50: 2.0 µM (HIF-1α/von Hippel-Lindau)[1]

分子量

363.41

Formula

C20H21N5O2

CAS 号

117953-17-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (137.59 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7517 mL 13.7586 mL 27.5171 mL
5 mM 0.5503 mL 2.7517 mL 5.5034 mL
10 mM 0.2752 mL 1.3759 mL 2.7517 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Xue X, et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based screening and cascade docking. PeerJ. 2016 Dec 15;4:e2757.

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