上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
ASP5878 纯度: 99.86%
ASP5878 是具有口服活性的、FGFR 1、2、3、和 4 的抑制剂,其对FGFR 1、2、3、和 4 激酶的 IC50 值分别为 0.47 nM、0.6 nM、0.74 nM 和 3.5 nM。ASP5878 具有潜在的抗肿瘤活性。
ASP5878 Chemical Structure
CAS No. : 1453208-66-6
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥3300 | In-stock | |
5 mg | ¥3000 | In-stock | |
10 mg | ¥4800 | In-stock | |
25 mg | ¥9500 | In-stock | |
50 mg | ¥14500 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
ASP5878 相关产品
•相关化合物库:
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Kinase Inhibitor Library
- Protein Tyrosine Kinase Compound Library
- Anti-Cancer Compound Library
- Clinical Compound Library
- Reprogramming Compound Library
- Anti-Lung Cancer Compound Library
- Angiogenesis Related Compound Library
- Targeted Diversity Library
- Anti-Liver Cancer Compound Library
生物活性 |
ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
ASP5878 shows potent antiproliferative activity in most human HCC cell lines[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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体内研究 (In Vivo) |
ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft and HCC orthotopic xenograft mouse model[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
407.37 |
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Formula |
C18H19F2N5O4 |
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CAS 号 |
1453208-66-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 250 mg/mL (613.69 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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