Disitamab vedotin(Synonyms: RC48)

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Disitamab vedotin (Synonyms: RC48) 纯度: 96.0%

Disitamab vedotin (RC48) 是一种抗体-药物偶联物 (ADC),包含抗人表皮生长因子受体2 (HER2) 的单克隆抗体,该单克隆抗体通过可降解连接子结合到细胞毒性剂 MMAE。Disitamab vedotin 增强抗肿瘤免疫。

Disitamab vedotin(Synonyms: RC48)

Disitamab vedotin Chemical Structure

CAS No. : 2136633-23-1

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生物活性

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity[1].

IC50 & Target[1]

HER2

 

体外研究
(In Vitro)

The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号

2136633-23-1

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Deeks ED. Disitamab Vedotin: First Approval. Drugs. 2021;81(16):1929-1935.

    [2]. Jiang J, et al. Preclinical safety profile of disitamab vedotin:a novel anti-HER2 antibody conjugated with MMAE. Toxicol Lett. 2020;324:30-37.

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