MLS000532223

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MLS000532223  纯度: 99.47%

MLS000532223 是一种选择性的，具有高亲和力的 Rho 家族 GTPases (Rho family GTPases) 抑制剂，其 EC50 值的范围为 16-120 μM。MLS000532223 能阻止 GTP 与几种 GTPases 相结合。

MLS000532223

MLS000532223 Chemical Structure

CAS No. : 16616-39-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3300 In-stock
5 mg ￥3000 In-stock
10 mg ￥4500 In-stock
50 mg ￥14000 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases[1].

IC50 & Target

EC50: 16-120 μM (Rho family GTPases)[1]
体外研究
(In Vitro)

MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1].
MLS000532223 modulates Rho-family GTP-binding kinetics[1].
MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation[1].
MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1].
MLS000532223 (10 μM) modulates actin remodeling in mast cells[1].
MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

251.24

Formula

C15H9NO3
CAS 号

16616-39-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (199.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9803 mL 19.9013 mL 39.8026 mL
5 mM 0.7961 mL 3.9803 mL 7.9605 mL
10 mM 0.3980 mL 1.9901 mL 3.9803 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15(1):10-20.

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