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Trastuzumab deruxtecan (Synonyms: DS-8201; DS-8201a)
Trastuzumab deruxtecan (DS-8201a) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-药物偶联物 (ADC)。Trastuzumab deruxtecan 由人源化抗 HER2 抗体,酶促裂解的肽接头和拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan 可用于 HER2 阳性乳腺癌和胃癌的研究。
Trastuzumab deruxtecan Chemical Structure
CAS No. : 1826843-81-5
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥3500 | In-stock | |
5 mg | ¥17500 | 询价 | |
10 mg | 询价 | ||
50 mg | 询价 |
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生物活性 |
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, and a topoisomerase I inhibitor. Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer[1][2]. |
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体外研究 (In Vitro) |
Trastuzumab deruxtecan (1 pM-10 nM; 5 days) inhibits the growth of HER2-positive KPL-4 cells, with an IC50 of 109.7 pM[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
Trastuzumab deruxtecan (3 mg/kg; a single i.v.) shows antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
CAS 号 |
1826843-81-5 |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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