上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Valecobulin hydrochloride (Synonyms: CKD-516 hydrochloride) 纯度: 98.90%
Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 (HY-130233) 的缬氨酸前体药和血管阻断剂 (VDA), 是一种强效的、β-微管蛋白聚合抑制剂,对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
Valecobulin hydrochloride Chemical Structure
CAS No. : 1240321-53-2
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥4410 | In-stock | |
5 mg | ¥3500 | In-stock | |
10 mg | ¥5500 | In-stock | |
50 mg | ¥16500 | In-stock | |
100 mg | ¥22500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Valecobulin hydrochloride 相关产品
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- Drug Repurposing Compound Library
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生物活性 |
Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 (HY-130233) and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2]. |
IC50 & Target |
β-tubulin polymerization[1] |
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体内研究 (In Vivo) |
Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
573.06 |
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Formula |
C26H29ClN6O5S |
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CAS 号 |
1240321-53-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (218.13 mM; Need ultrasonic) H2O : 50 mg/mL (87.25 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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