nor-NOHA acetate(Synonyms: Nω-Hydroxy-nor-L-arginine acetate)

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nor-NOHA acetate (Synonyms: Nω-Hydroxy-nor-L-arginine acetate)

nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) 是一种特异性、可逆的 arginase 抑制剂，在缺氧条件下，可诱导 ARG2 表达细胞的凋亡。具有抗白血病的作用，同时在内皮功能障碍、免疫抑制及代谢中有效。

nor-NOHA acetate(Synonyms: Nω-Hydroxy-nor-L-arginine acetate)

nor-NOHA acetate Chemical Structure

CAS No. : 1140844-63-8

规格 价格 是否有货
10 mM * 1 mL in Water ￥2640 询问价格 & 货期
5 mg ￥2900 询问价格 & 货期
10 mg ￥4800 询问价格 & 货期

* Please select Quantity before adding items.

nor-NOHA acetate 的其他形式现货产品:

nor-NOHA monoacetate

nor-NOHA acetate 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Small Molecule Immuno-Oncology Compound Library
  • Anti-Cancer Metabolism Compound Library

生物活性

nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].

IC50 & Target

Arginase[1]
分子量

296.28

Formula

C9H20N4O7
CAS 号

1140844-63-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 200 mg/mL (675.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3752 mL 16.8759 mL 33.7519 mL
5 mM 0.6750 mL 3.3752 mL 6.7504 mL
10 mM 0.3375 mL 1.6876 mL 3.3752 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.

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