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LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride) 纯度: 99.70%
LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂,是 拓扑异构酶 1 (Top1) 抑制剂,具有抗肿瘤活性。
LMP744 hydrochloride Chemical Structure
CAS No. : 308246-57-3
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥3500 | In-stock | |
5 mg | ¥9500 | In-stock | |
10 mg | ¥15000 | In-stock | |
50 mg | ¥45000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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LMP744 hydrochloride 相关产品
•相关化合物库:
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
生物活性 |
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[2]
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体内研究 (In Vivo) |
LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
488.92 |
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Formula |
C24H25ClN2O7 |
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CAS 号 |
308246-57-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 105 mg/mL (214.76 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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