TMBIM6 antagonist-1

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TMBIM6 antagonist-1  纯度: 99.80%

TMBIM6 antagonist-1 是一个有潜力的 TMBIM6 拮抗剂，抑制 TMBIM6 与 mTORC2 结合，降低 mTORC2 活性，调节TMBIM6 释放 Ca2+。

TMBIM6 antagonist-1

TMBIM6 antagonist-1 Chemical Structure

CAS No. : 123134-61-2

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生物活性

TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+[1].

体外研究
(In Vitro)

TMBIM6 antagonist-1 (BIA, 0.5-10 μM, 3 days) significantly and dose-dependently inhibits cell viability in HT1080, MCF7, MDA-MB-2341 and SKBR3 cells, with IC50 values of 1.7 ± 0.1 μM for HT1080, 2.6 ± 0.4 μM for MCF cells, 2.6 ± 0.5 μM for MDA-MB-231 cells, and 2.4 ± 0.4 μM for SKBR3 cells, respectively[1].
TMBIM6 antagonist-1 (BIA, 10 μM) treatment decreases cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells, not TMBIM6 KO HT1080 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HT1080, MCF7, MDA-MB-2341 and SKBR3 cells.
Concentration: 0.5-10 μM.
Incubation Time: 3 days.
Result: Inhibited cell viability.

Western Blot Analysis[1]

Cell Line: WT and TMBIM6 KO HT1080 cells.
Concentration: 0, 2, 5 μM.
Incubation Time:
Result: Downregulated the protein levels of AKT-pS473.

体内研究
(In Vivo)

TMBIM6 antagonist-1 (1 mg/kg, IP 5 days per week during 25 days) significantly impaires cell-driven tumor growth[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells)[1].
Dosage: 1 mg/kg.
Administration: IP 5 days per week during 25 days.
Result: Impaired cell-driven tumor growth.

分子量

268.27

Formula

C15H12N2O3
CAS 号

123134-61-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (186.38 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7276 mL 18.6379 mL 37.2759 mL
5 mM 0.7455 mL 3.7276 mL 7.4552 mL
10 mM 0.3728 mL 1.8638 mL 3.7276 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hyun-Kyoung Kim, et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun. 2020 Aug 11;11(1):4012.

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