Angiotensin II 5-valine(Synonyms: 血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II)

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Angiotensin II 5-valine (Synonyms: 血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II) 纯度: 99.77%

Angiotensin II 5-valine 是血管紧张素受体 (angiotensin receptor) 的激动剂。

Angiotensin II 5-valine(Synonyms: 血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II)

Angiotensin II 5-valine Chemical Structure

CAS No. : 58-49-1

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥624 In-stock
5 mg ￥450 In-stock
10 mg ￥550 In-stock
50 mg ￥690 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Angiotensin II 5-valine is an agonist of angiotensin receptor.

IC50 & Target

Angiotensin receptor[1].
体内研究
(In Vivo)

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1032.15

Formula

C49H69N13O12
CAS 号

58-49-1
Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe
Sequence Shortening

DRVYVHPF
中文名称

血管紧张素 Ⅱ 5-缬氨酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

H2O : 100 mg/mL (96.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9689 mL 4.8443 mL 9.6885 mL
5 mM 0.1938 mL 0.9689 mL 1.9377 mL
10 mM 0.0969 mL 0.4844 mL 0.9689 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.
Animal Administration
[1]

Rats[1]
Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.

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