BODIPY 581/591 C11

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BODIPY 581/591 C11 

C11-BODIPY581/591 是脂质氧化 (lipid oxidation) 的荧光比值探针。C11-BODIPY581/591 常用于评价模型膜系统和活细胞中的脂质过氧化和抗氧化作用。C11-BODIPY581/591 是用于铁死亡研究的常用手段。

BODIPY 581/591 C11

BODIPY 581/591 C11 Chemical Structure

CAS No. : 217075-36-0

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生物活性

C11-BODIPY581/591 is a fluorescent ratio-probe of lipid oxidation. C11-BODIPY581/591 is often used for indexing lipid peroxidation and antioxidant efficacy in model membrane systems and living cells. C11-BODIPY581/591 is applied in the quantitation of ferroptosis[1].

体外研究
(In Vitro)

C11-BODIPY581/591 can easily enter membranes and exhibits good spectral separation of the nonoxidized (595 nm) and oxidized (520 nm) forms[1].
Stock solutions of C11 BODIPY581/591 are made by dissolving 1 mg in 20 mM organic solvent.
Cells are labeled in DMEM or PBS with 1-20 μM C11-BODIPY581/591 at 37°C, 30 min before the experiment.
Alternatively, cells are incubated in DMEM with 1-10 μM preoxidized C11-BODIPY581/591.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

504.42

Formula

C30H35BF2N2O2

CAS 号

217075-36-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Gregor P C Drummen, et al. C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology. Free Radic Biol Med. 2002 Aug 15;33(4):473-90.

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