Nitidine chloride(Synonyms: 氯化两面针碱)

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Nitidine chloride (Synonyms: 氯化两面针碱) 纯度: 99.61%

Nitidine chloride 是可从Zanthoxylum nitidum (Roxb) DC 中分离得到一种具有抗疟疾活性的化合物。Nitidine chloride 通过多个靶点通路，发挥抗癌活性，如诱导凋亡，抑制STAT3、DNA拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。Nitidine chloride通过MAPK和NF-kB途径抑制Lps诱导的炎性细胞因子的产生。

Nitidine chloride(Synonyms: 氯化两面针碱)

Nitidine chloride Chemical Structure

CAS No. : 13063-04-2

规格 价格 是否有货 数量
5 mg ￥800 In-stock
10 mg ￥1400 In-stock
20 mg ￥2300 In-stock
50 mg   询价  
100 mg   询价  

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Nitidine chloride 相关产品

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生物活性

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6].

分子量

383.82

Formula

C21H18ClNO4
CAS 号

13063-04-2
中文名称

氯化两面针碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

DMSO : 2 mg/mL (5.21 mM; Need ultrasonic)

*Nitidine chloride is usually formulated as a suspension.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6054 mL 13.0269 mL 26.0539 mL
5 mM 0.5211 mL 2.6054 mL 5.2108 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Chen J, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87.

    [2]. Wang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50.

    [3]. Pan X, et al. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27;313(2):181-91.

    [4]. Fang Z, et al. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr;66:210-6.

    [5]. Liu LM, et al. DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. Int J Oncol. 2018 Nov;53(5):1897-1912.

    [6]. Bouquet J, et al. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012 Mar 9;11:67.

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