L67(Synonyms: DNA Ligase Inhibitor)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

L67 (Synonyms: DNA Ligase Inhibitor) 纯度: ≥98.0%

L67是一种新型的竞争性 DNA连接酶抑制剂，抑制DNA连接酶I和III, IC50为10μM。

L67(Synonyms: DNA Ligase Inhibitor)

L67 Chemical Structure

CAS No. : 325970-71-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1210 In-stock
5 mg ￥1100 In-stock
10 mg ￥1800 In-stock
50 mg ￥6600 In-stock
100 mg ￥9900 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

L67 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library

生物活性

L67 is a novel, competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM. IC50 value: 10 μM [1] Target: DNA ligases in vitro: L67 significantly increases the cytotoxicity of DNA damaging agents.[1] L67 also inhibits cell proliferation. [2]

分子量

486.11

Formula

C16H14Br2N4O4
CAS 号

325970-71-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 33 mg/mL (67.89 mM)

H2O : 1 mg/mL (2.06 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0571 mL 10.2857 mL 20.5715 mL
5 mM 0.4114 mL 2.0571 mL 4.1143 mL
10 mM 0.2057 mL 1.0286 mL 2.0571 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhong S, et al. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-4562.

    [2]. Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-3177.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务