AMP-PCP disodium

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AMP-PCP disodium  纯度: ≥99.0%

AMP-PCP disodium 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP disodium 结合有利于 Hsp90 活性同型二聚体的形成。

AMP-PCP disodium

AMP-PCP disodium Chemical Structure

CAS No. : 7414-56-4

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥3383 In-stock
1 mg ￥1300 In-stock
5 mg ￥2800 In-stock
10 mg   询价  
50 mg   询价  

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AMP-PCP disodium 相关产品

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生物活性

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1].

IC50 & Target[1]

HSP90

3.8 μM (Kd)

体外研究
(In Vitro)

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

549.17

Formula

C11H16N5Na2O12P3
CAS 号

7414-56-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 100 mg/mL (182.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8209 mL 9.1046 mL 18.2093 mL
5 mM 0.3642 mL 1.8209 mL 3.6419 mL
10 mM 0.1821 mL 0.9105 mL 1.8209 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

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