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DL-Buthionine-(S,R)-sulfoximine hydrochloride (Synonyms: Buthionine sulfoximine hydrochloride; BSO hydrochloride)
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) 是谷氨酰半胱氨酸合成酶生物合成的有效抑制剂。
DL-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure
规格 | 价格 | 是否有货 | |
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10 mM * 1 mL in DMSO | ¥660 | 询问价格 & 货期 | |
50 mg | ¥600 | 询问价格 & 货期 |
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DL-Buthionine-(S,R)-sulfoximine hydrochloride 的其他形式现货产品:
DL-Buthionine-(S,R)-sulfoximine hydrochloride 相关产品
•相关化合物库:
- Clinical Compound Library Plus
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- Anti-Cancer Compound Library
- Clinical Compound Library
- Ferroptosis Compound Library
生物活性 |
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis. |
IC50 & Target |
Glutamylcysteine synthetase[1] |
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体外研究 (In Vitro) |
Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
258.77 |
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Formula |
C8H19ClN2O3S |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:
H2O : ≥ 140 mg/mL (541.02 mM) DMSO : ≥ 125 mg/mL (483.05 mM) Ethanol : 25 mg/mL (96.61 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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