NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCF^β-TrCP, induces mutant β-catenin degradation, with an EC₅₀ of 3.8 nM^[1].

EC50: 3.8 nM (β-Catenin-SCF^β-TrCP)^[1]

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

545.36

C₂₃H₁₇Cl₂F₃N₂O₄S

2438637-61-5

Room temperature in continental US; may vary elsewhere.

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

In Vitro: 

DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic)

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

• [1]. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.